Rheumatoid arthritis is a long term inflammatory disease that typically affects joints and surrounding tissues in one’s hands and feet. Previous studies assumed that Prolactin hormone has a role in disease severity, but a recently published study questioned that relation.
The study was carried at Aalborg University Esbjerg, Denmark by a group of researchers and has recently been published in a Journal of Research in Endocrinology. Scientists stated that “The objective of (the study) is to analyze the serum level of Prolactin (s-PRL) in 307 treated patients with Rheumatoid Arthritis (RA), and its association to disease activity, demographics, serological and clinical variables.”
The study finds that the treated patients “were characterized by demographic, serological and clinical variables, in addition to assessment of disease activity by DAS28 (3w-CRP) score. Prolactin was analyzed by a double sandwich immune analysis.”
After Data analysis, the researchers “demonstrated that 4 out of 307 RA patients had high level of s-PRL, all of them with low disease activity score. » Therfore, they come to a conclusion «that s-PRL did not correlate to disease activity, serology or demographic factors in 307 treated patients with rheumatoid arthritis.” Thus, based on the results they «therefore question the hypothesis that PRL may play a role in disease severity and the development of rheumatoid arthritis in humans.”
It is worth mentioning that “it has been reported a correlation between disease activity and the level of PRL in synovial fluid, and a correlation of s-PRL to the total Larsen radiographic score as demonstrated by Fojtikova M et. al. (2010), implicating that prolactin may play a role in disease severity and the process of joint damage” the study mentioned.